Pub. Date : 2021 Mar 26
PMID : 33575476
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin enhances anti-cancer effects of cisplatin in meningioma through AMPK-mTOR signaling pathways. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | Additionally, metformin activated adenosine monophosphate activated protein kinase (AMPK) and repressed the mammalian target of rapamycin (mTOR) signaling pathways via an AMPK-dependent mechanism. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | Additionally, metformin activated adenosine monophosphate activated protein kinase (AMPK) and repressed the mammalian target of rapamycin (mTOR) signaling pathways via an AMPK-dependent mechanism. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Additionally, metformin activated adenosine monophosphate activated protein kinase (AMPK) and repressed the mammalian target of rapamycin (mTOR) signaling pathways via an AMPK-dependent mechanism. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | Furthermore, our xenograft murine model confirmed that metformin enhanced cisplatin"s anti-cancer effect by upregulation of AMPK and downregulation of mTOR signaling pathways. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 6 | These results demonstrate metformin enhanced the anti-cancer effect of cisplatin in meningioma in vitro and in vivo, an effect mediated through the activation of AMPK and repression of mTOR signaling pathways. | Metformin | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |