Pub. Date : 1988 Mar-Apr
PMID : 3356413
8 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Phenobarbital induction of cytochrome P-450 b,e genes is dependent on protein synthesis. | Phenobarbital | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 2 | Phenobarbital induces liver cytochrome P-450 b,e proteins mainly by increasing the rate of transcription of these genes. | Phenobarbital | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 3 | The mechanism responsible for the phenobarbital increment in the rate of transcription of cytochrome P-450 b,e genes is unknown. | Phenobarbital | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 4 | The objective of this study was to assess whether active protein synthesis was needed for phenobarbital to induce the liver cytochrome P-450 b,e genes. | Phenobarbital | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 5 | While phenobarbital increased cytochrome P-450 b,e mRNAs about 12-fold at 3 hr, this induction was abolished by cycloheximide. | Phenobarbital | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 6 | To define whether the absence of protein synthesis in hepatocytes inhibited the phenobarbital induction of cytochrome P-450 at the transcriptional level, in vitro transcription rates using isolated nuclei were measured. | Phenobarbital | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 7 | After phenobarbital administration, there was about a 20-fold increment in transcriptional rate of cytochrome P-450 b,e genes. | Phenobarbital | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |
| 8 | It is proposed that either preexisting regulatory proteins or transacting factors dependent on active protein synthesis participate in the regulation of liver cytochrome P-450 b,e gene transcription after phenobarbital. | Phenobarbital | cytochrome P450 family 4 subfamily F member 3 | Homo sapiens |