Pub. Date : 2021 Jul 1
PMID : 33545599
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Both EGCG and GCG inhibited tyrosinase in a mixed manner with the IC50 values of 39.4 +- 0.54 muM and 36.8 +- 0.21 muM, and showed a synergism with their combination, while EGCG and GCG combined with kojic acid (IC50 = 19.2 +- 0.26 muM) exhibited antagonism and additive effect, respectively. | epigallocatechin gallate | tyrosinase | Homo sapiens |
| 2 | Both EGCG and GCG inhibited tyrosinase in a mixed manner with the IC50 values of 39.4 +- 0.54 muM and 36.8 +- 0.21 muM, and showed a synergism with their combination, while EGCG and GCG combined with kojic acid (IC50 = 19.2 +- 0.26 muM) exhibited antagonism and additive effect, respectively. | epigallocatechin gallate | tyrosinase | Homo sapiens |
| 3 | EGCG and GCG interacted with tyrosinase mainly by hydrogen bonding and hydrophobic interactions and induced a looser conformation of tyrosinase. | epigallocatechin gallate | tyrosinase | Homo sapiens |
| 4 | EGCG and GCG interacted with tyrosinase mainly by hydrogen bonding and hydrophobic interactions and induced a looser conformation of tyrosinase. | epigallocatechin gallate | tyrosinase | Homo sapiens |
| 5 | Molecular docking indicated that EGCG and GCG bound to the active center of tyrosinase and interacted with copper ions and key amino acid residues. | epigallocatechin gallate | tyrosinase | Homo sapiens |
| 6 | Molecular dynamics simulation further characterized the structure and property of EGCG/GCG-tyrosinase complex. | epigallocatechin gallate | tyrosinase | Homo sapiens |