Title : The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function.

Pub. Date : 2021

PMID : 33531986






1 Functional Relationships(s)
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Protein Name
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1 COL11A1/Akt disturbed the BCL-2/BAX balance, inhibiting cytochrome c (Cyt-C) release and binding of Apaf-1/procaspase-9/Cyt-C, which suppressed the apoptotic program and induced GEM resistance in pancreatic cancer cells. gemcitabine BCL2 associated X, apoptosis regulator Homo sapiens