Title : KRAS-Mutated, Estrogen Receptor-Positive Low-Grade Serous Ovarian Cancer: Unraveling an Exceptional Response Mystery.

Pub. Date : 2021 Apr

PMID : 33528846






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1 KEY POINTS: This report demonstrates remarkable response for KRAS-mutated, ER-positive low-grade serous ovarian cancer patient treated with trametinib (MEK inhibitor) and letrozole (aromatase inhibitor), despite prior progression on similar agents including tamoxifen (estrogen modulator). Tamoxifen epiregulin Homo sapiens