Title : Chemical mitochondrial uncouplers share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NFκB nuclear translocation.

Pub. Date : 2021 Mar 1

PMID : 33524445






4 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Activation of NLRP3 inflammasome is implicated in varieties of pathologies, the aim of the present study is to characterize the effect and mechanism of mitochondrial uncouplers on NLRP3 inflammasome activation by using three types of uncouplers, niclosamide, CCCP and BAM15. Niclosamide NLR family pyrin domain containing 3 Homo sapiens
2 Activation of NLRP3 inflammasome is implicated in varieties of pathologies, the aim of the present study is to characterize the effect and mechanism of mitochondrial uncouplers on NLRP3 inflammasome activation by using three types of uncouplers, niclosamide, CCCP and BAM15. Niclosamide NLR family pyrin domain containing 3 Homo sapiens
3 Niclosamide, CCCP and BAM15 inhibited LPS plus ATP-induced increases of NLRP3 protein and IL-1beta mRNA levels in RAW264.7 macrophages and THP-1 derived macrophages. Niclosamide NLR family pyrin domain containing 3 Homo sapiens
4 In conclusion, chemical mitochondrial uncouplers niclosamide, CCCP and BAM15 share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NFkappaB nuclear translocation. Niclosamide NLR family pyrin domain containing 3 Homo sapiens