PMID-sentid Pub_year Sent_text comp_official_name comp_offsetprotein_name organism prot_offset 33524445-1 2021 Activation of NLRP3 inflammasome is implicated in varieties of pathologies, the aim of the present study is to characterize the effect and mechanism of mitochondrial uncouplers on NLRP3 inflammasome activation by using three types of uncouplers, niclosamide, CCCP and BAM15. Niclosamide 246-257 NLR family pyrin domain containing 3 Homo sapiens 14-19 33524445-1 2021 Activation of NLRP3 inflammasome is implicated in varieties of pathologies, the aim of the present study is to characterize the effect and mechanism of mitochondrial uncouplers on NLRP3 inflammasome activation by using three types of uncouplers, niclosamide, CCCP and BAM15. Niclosamide 246-257 NLR family pyrin domain containing 3 Homo sapiens 180-185 33524445-2 2021 Niclosamide, CCCP and BAM15 inhibited LPS plus ATP-induced increases of NLRP3 protein and IL-1beta mRNA levels in RAW264.7 macrophages and THP-1 derived macrophages. Niclosamide 0-11 NLR family pyrin domain containing 3 Homo sapiens 72-77 33524445-5 2021 In conclusion, chemical mitochondrial uncouplers niclosamide, CCCP and BAM15 share common inhibitory effect on NLRP3 inflammasome activation through inhibiting NFkappaB nuclear translocation. Niclosamide 49-60 NLR family pyrin domain containing 3 Homo sapiens 111-116