Title : NAD(H) phosphates mediate tetramer assembly of human C-terminal binding protein (CtBP).

Pub. Date : 2021 Jan-Jun

PMID : 33524397






2 Functional Relationships(s)
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1 Using multi-angle light scattering (MALS) we show that ADP is able to promote tetramer formation of both CtBP1 and CtBP2, whereas AMP promotes tetramer assembly of CtBP1, but not CtBP2. Adenosine Monophosphate C-terminal binding protein 1 Homo sapiens
2 Our crystal structures of CtBP1 with AMP reveal participation of the adenosine phosphate in the tetrameric interface, pinpointing its central role in NAD(H) linked assembly. Adenosine Monophosphate C-terminal binding protein 1 Homo sapiens