Title : Identification of a novel association for the WWOX/HIF1A axis with gestational diabetes mellitus (GDM).

Pub. Date : 2021

PMID : 33520443






2 Functional Relationships(s)
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1 Background: Although the WW-domain-containing oxidoreductase (WWOX)/Hypoxia-inducible factor 1 (HIF1) pathway is a well-known regulator of cellular glucose and energy metabolism in pathophysiological processes, its role in gestational diabetes mellitus (GDM), remains elusive. Glucose hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Quantitative RT-PCR was performed to determine gene expression profiles of the WWOX/HIF1A-related genes, including those involved in glucose transport (SLC2A1, SLC2A4), glycolytic pathway (HK2, PKM2, PFK, LDHA), Wnt pathway (DVL2, CTNNB1), and inflammatory response (NFKB1). Glucose hypoxia inducible factor 1 subunit alpha Homo sapiens