Title : Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation of SIRT1.

Pub. Date : 2021 Sep

PMID : 33517853






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Metformin attenuates ischemia/reperfusion-induced apoptosis of cardiac cells by downregulation of p53/microRNA-34a via activation SIRT1. Metformin Wistar clone pR53P1 p53 pseudogene Rattus norvegicus
2 Metformin decreased the deacetylation activity of SIRT 1 resulting in reduced Ac-p53 levels, which reduced the levels of pri-miR-34a. Metformin Wistar clone pR53P1 p53 pseudogene Rattus norvegicus