Title : Effect and mechanism of miR-217 on drug resistance, invasion and metastasis of ovarian cancer cells through a regulatory axis of CUL4B gene silencing/inhibited Wnt/β-catenin signaling pathway activation.

Pub. Date : 2021 Jan

PMID : 33506897






2 Functional Relationships(s)
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1 OBJECTIVE: To explore the effect and mechanism of miR-217 in cisplatin resistance, as well as invasion and metastasis of ovarian cancer by inhibiting the expression of Cullin 4B (CUL4B) and the activation of Wnt/beta-catenin signaling pathway. Cisplatin catenin beta 1 Homo sapiens
2 MiR-217 can silence the expression of this gene, and inhibit the activation of Wnt/beta-catenin signaling pathway to enhance the cisplatin sensitivity and reverse drug resistance, inhibit cell invasion and migration, and promote cell apoptosis. Cisplatin catenin beta 1 Homo sapiens