Title : Reversine, a selective MPS1 inhibitor, induced autophagic cell death via diminished glucose uptake and ATP production in cholangiocarcinoma cells.

Pub. Date : 2021

PMID : 33505802






2 Functional Relationships(s)
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1 Additionally, this study demonstrated for the first time that reversine could diminish the expression of Hypoxia-Inducible Factor 1- alpha (HIF-1alpha) and glucose transporter 1 (GLUT1), resulting in a reduction of glucose uptake and energy production in CCA cell lines. 2-(4-morpholinoanilino)-6-cyclohexylaminopurine hypoxia inducible factor 1 subunit alpha Homo sapiens
2 Additionally, this study demonstrated for the first time that reversine could diminish the expression of Hypoxia-Inducible Factor 1- alpha (HIF-1alpha) and glucose transporter 1 (GLUT1), resulting in a reduction of glucose uptake and energy production in CCA cell lines. 2-(4-morpholinoanilino)-6-cyclohexylaminopurine hypoxia inducible factor 1 subunit alpha Homo sapiens