Title : CDK2 limits the highly energetic secretory program of mature β cells by restricting PEP cycle-dependent KATP channel closure.

Pub. Date : 2021 Jan 26

PMID : 33503433






3 Functional Relationships(s)
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1 In the absence of any changes in beta cell mass, maturity, or proliferation, genetic deletion of Cdk2 in adult beta cells enhanced insulin secretion from isolated islets and improved glucose tolerance in vivo. Glucose cyclin dependent kinase 2 Homo sapiens
2 In parallel with reduced beta cell recruitment, CDK2 restricts oxidative glucose metabolism while promoting glucose-dependent amplification of insulin secretion. Glucose cyclin dependent kinase 2 Homo sapiens
3 In parallel with reduced beta cell recruitment, CDK2 restricts oxidative glucose metabolism while promoting glucose-dependent amplification of insulin secretion. Glucose cyclin dependent kinase 2 Homo sapiens