Title : Reactive Oxygen Species-Mediated Inflammation and Apoptosis in Hand-Foot Syndrome Induced by PEGylated Liposomal Doxorubicin.

Pub. Date : 2021

PMID : 33500617






3 Functional Relationships(s)
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1 The mechanism was probably attributed to the accumulation of PLD in the skin tissues during the long-term circulation and further the induction of ROS to cause the oxidative damage of keratinocytes owing to the sustained release of doxorubicin from PLD. Reactive Oxygen Species glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
2 Conclusion: The ROS generation induced by the administration of PLD has been identified to be a crucial factor in the development of HFS, which could be used as a potential therapeutic target to alleviate the HFS symptom of PLD administration. Reactive Oxygen Species glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens
3 Conclusion: The ROS generation induced by the administration of PLD has been identified to be a crucial factor in the development of HFS, which could be used as a potential therapeutic target to alleviate the HFS symptom of PLD administration. Reactive Oxygen Species glycosylphosphatidylinositol specific phospholipase D1 Homo sapiens