Title : Gossypol, a novel modulator of VCP, induces autophagic degradation of mutant huntingtin by promoting the formation of VCP/p97-LC3-mHTT complex.

Pub. Date : 2021 Oct

PMID : 33495516






1 Functional Relationships(s)
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1 Taken together, gossypol acetate acted through a gain-of-function way to induce the formation of VCP-LC3-mHTT ternary complex, triggering autophagic degradation of mHTT. gossypol acetic acid valosin containing protein Mus musculus