| Protein Name | valosin containing protein |
|---|---|
| Organism | Mus musculus |
| Gene ID | 269523 |
| Gene Symbol | Vcp |
| UniProt | Q01853 (TERA_MOUSE) |
| Relationships |
Total Number of functionally related compound(s) :
40
Total Number of Articles : 44 |
Description |
valosin containing protein |
| Gene Summary |
Enables several functions, including ATP hydrolysis activity; K48-linked polyubiquitin modification-dependent protein binding activity; and adenyl ribonucleotide binding activity. Involved in ATP metabolic process; positive regulation of mitochondrial membrane potential; and proteasomal protein catabolic process. Acts upstream of or within activation of cysteine-type endopeptidase activity involved in apoptotic process; aggresome assembly; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum membrane and synapse. Part of ATPase complex; VCP-NSFL1C complex; and endoplasmic reticulum membrane. Is expressed in several structures, including cerebral cortex; early embryo; gonad; gut; and triceps surae muscle. Used to study inclusion body myopathy with Paget disease of bone and frontotemporal dementia. Human ortholog(s) of this gene implicated in several diseases, including Charcot-Marie-Tooth disease type 2Y; Paget's disease of bone; amyotrophic lateral sclerosis type 14; inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 1; and inclusion body myositis. Orthologous to human VCP (valosin containing protein). [provided by Alliance of Genome Resources, Apr 2022] |
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