Title : Apolipoprotein E deficiency induces a progressive increase in tissue iron contents with age in mice.

Pub. Date : 2021 Apr

PMID : 33493903






1 Functional Relationships(s)
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1 Subsequent investigations showed that the increased iron in the liver and spleen was due to phosphorylated extracellular regulated protein kinases (pERK) mediated up-regulation of transferrin receptor 1 (TfR1), and nuclear factor erythroid 2-related factor-2 (Nrf2)-dependent down-regulation of ferroportin 1. Iron solute carrier family 40 (iron-regulated transporter), member 1 Mus musculus