Pub. Date : 2021 Jan 22
PMID : 33490902
2 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | High-throughput rational design of the remdesivir binding site in the RdRp of SARS-CoV-2: implications for potential resistance. | remdesivir | ORF1a polyprotein;ORF1ab polyprotein | Severe acute respiratory syndrome coronavirus 2 |
| 2 | Using a rational ligand-based interface design complemented with mutational mapping, we generated a total of 100,000 mutations and provided insight into the functional outcomes of mutations in the remdesivir-binding site in nsp12 subunit of RdRp. | remdesivir | ORF1a polyprotein;ORF1ab polyprotein | Severe acute respiratory syndrome coronavirus 2 |