Title : Stimulation of Sigma-1 Receptor Protects against Cardiac Fibrosis by Alleviating IRE1 Pathway and Autophagy Impairment.

Pub. Date : 2021

PMID : 33488945






2 Functional Relationships(s)
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1 Fluvoxamine stimulation of Sig1R restored autophagic flux in cardiac fibroblasts, indicating that Sig1R appears to play a protective role in the activation of cardiac fibroblasts by inhibiting the IRE1 pathway and restoring autophagic flux. Fluvoxamine sigma non-opioid intracellular receptor 1 Rattus norvegicus
2 Fluvoxamine stimulation of Sig1R restored autophagic flux in cardiac fibroblasts, indicating that Sig1R appears to play a protective role in the activation of cardiac fibroblasts by inhibiting the IRE1 pathway and restoring autophagic flux. Fluvoxamine sigma non-opioid intracellular receptor 1 Rattus norvegicus