Pub. Date : 2021 Jan 11
PMID : 33486250
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Curcumin significantly increased phosphorylation of Akt [Thr308] and attenuated fluoride-mediated caspase-3 cleavage and DNA damage marker gammaH2AX expression. | Curcumin | AKT serine/threonine kinase 1 | Homo sapiens |
| 2 | Curcumin-mediated attenuation of caspase-3 activation was reversed by Akt inhibitor LY294002 (LY). | Curcumin | AKT serine/threonine kinase 1 | Homo sapiens |
| 3 | These results suggest that curcumin inhibited fluoride-mediated apoptosis via Akt activation, but DNA damage was suppressed by other pathways. | Curcumin | AKT serine/threonine kinase 1 | Homo sapiens |
| 4 | These results suggest that curcumin-induced Ac-p53 and p21 led to cell cycle arrest, while curcumin attenuated fluoride-mediated apoptosis via activation of Akt and suppressed fluoride-mediated DNA damage. | Curcumin | AKT serine/threonine kinase 1 | Homo sapiens |