Pub. Date : 2021 Jan 15
PMID : 33486244
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Cadmium promotes breast cancer cell proliferation, migration and invasion by inhibiting ACSS2/ATG5-mediated autophagy. | Cadmium | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 2 | GSEA and GeneMANIA were utilized to demonstrate that the Cd-induced decrease in ACSS2 expression mechanistically inhibited ATG5-dependent autophagy in BC cells. | Cadmium | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 3 | Importantly, ACSS2 overexpression increased the level of H3K27 acetylation in the promoter region of ATG5, and this result maintained autophagic flux and abolished the Cd-induced increases in proliferation, migration and invasion. | Cadmium | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 4 | These findings indicated that the promoting effect of Cd on BC cell proliferation, migration and invasion through the impairment of ACSS2/ATG5-dependent autophagic flux suggests a new mechanism for BC cell proliferation and metastasis stimulated by Cd. | Cadmium | acyl-CoA synthetase short chain family member 2 | Homo sapiens |
| 5 | These findings indicated that the promoting effect of Cd on BC cell proliferation, migration and invasion through the impairment of ACSS2/ATG5-dependent autophagic flux suggests a new mechanism for BC cell proliferation and metastasis stimulated by Cd. | Cadmium | acyl-CoA synthetase short chain family member 2 | Homo sapiens |