Title : TNFα induces endothelial dysfunction in rheumatoid arthritis via LOX-1 and arginase 2: reversal by monoclonal TNFα antibodies.

Pub. Date : 2022 Jan 7

PMID : 33483748






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1 METHODS AND RESULTS: Endothelium-dependent relaxations to acetylcholine were reduced in aortae of two TNFalpha transgenic mouse lines with either mild (Tg3647) or severe (Tg197) forms of RA in a time- and severity-dependent fashion as assessed by organ chamber myograph. Acetylcholine tumor necrosis factor Mus musculus