Title : MYCN-Amplified Neuroblastoma Is Addicted to Iron and Vulnerable to Inhibition of the System Xc-/Glutathione Axis.

Pub. Date : 2021 Apr 1

PMID : 33483374






1 Functional Relationships(s)
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1 Accumulating iron caused reactive oxygen species (ROS) production, and MYCN-amplified neuroblastomas showed enhanced reliance on the system Xc- cystine/glutamate antiporter for ROS detoxification through increased transcription of this receptor. Reactive Oxygen Species MYCN proto-oncogene, bHLH transcription factor Homo sapiens