Title : Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin.

Pub. Date : 2021 Jan 21

PMID : 33479328






4 Functional Relationships(s)
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1 Hyperglycemia-induced VEGF and ROS production in retinal cells is inhibited by the mTOR inhibitor, rapamycin. Sirolimus vascular endothelial growth factor A Rattus norvegicus
2 Determine the impact of the mTOR inhibitor, rapamycin, on the hyperglycemia-induced expression of vascular endothelial growth factor (VEGF) and the production of reactive oxygen species (ROS) in retinal cells. Sirolimus vascular endothelial growth factor A Rattus norvegicus
3 Determine the impact of the mTOR inhibitor, rapamycin, on the hyperglycemia-induced expression of vascular endothelial growth factor (VEGF) and the production of reactive oxygen species (ROS) in retinal cells. Sirolimus vascular endothelial growth factor A Rattus norvegicus
4 In rat retina, rapamycin attenuates the diabetes-induced VEGF overexpression, and in cultured Muller cells and HRMECs, inhibits the hyperglycemia-induced boost ROS. Sirolimus vascular endothelial growth factor A Rattus norvegicus