Title : The Positive Allosteric Modulation of alpha7-Nicotinic Cholinergic Receptors by GAT107 Increases Bacterial Lung Clearance in Hyperoxic Mice by Decreasing Oxidative Stress in Macrophages.

Pub. Date : 2021 Jan 19

PMID : 33477969






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1 This study reports that the activation of the alpha7 nicotinic acetylcholine receptor (alpha7nAChR) with the delete allosteric agonistic-positive allosteric modulator, GAT107, decreases the bacterial burden in mouse lungs by improving hyperoxia-induced lung redox imbalance. Acetylcholine cholinergic receptor, nicotinic, alpha polypeptide 7 Mus musculus