Title : Autophagy activation, lipotoxicity and lysosomal membrane permeabilization synergize to promote pimozide- and loperamide-induced glioma cell death.

Pub. Date : 2021 Nov

PMID : 33461384






1 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 In continuation of previous work, we demonstrate that pimozide and loperamide trigger an ATG5- and ATG7 (autophagy related 5 and 7)-dependent type of cell death that is significantly reduced with cathepsin inhibitors and the lipid reactive oxygen species (ROS) scavenger alpha-tocopherol in MZ-54 GBM cells. Pimozide autophagy related 7 Homo sapiens