Protein Name autophagy related 7
Organism Homo sapiens
Gene ID 10533
Gene Symbol

ATG7

UniProt O95352 (ATG7_HUMAN), B3KQM6 (B3KQM6_HUMAN)
Relationships Total Number of functionally related compound(s) : 260
Total Number of Articles : 326
Description

autophagy related 7

Gene Summary

This gene encodes an E1-like activating enzyme that is essential for autophagy and cytoplasmic to vacuole transport. The encoded protein is also thought to modulate p53-dependent cell cycle pathways during prolonged metabolic stress. It has been associated with multiple functions, including axon membrane trafficking, axonal homeostasis, mitophagy, adipose differentiation, and hematopoietic stem cell maintenance. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]

synonyms
  • ubiquitin-like modifier-activating enzyme ATG7
  • APG7 autophagy 7-like
  • ATG12-activating enzyme E1 ATG7
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Properties