Pub. Date : 2021 Feb
PMID : 33461143
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dihydromyricetin reverses MRP2-induced multidrug resistance by preventing NF-kappaB-Nrf2 signaling in colorectal cancer cell. | dihydromyricetin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 2 | BACKGROUD: Dihydromyricetin (DMY), a natural flavonoid compound from the leaves of the Chinese medicinal herb Vitis heyneana, has been shown to have the potential to combat chemoresistance by inhibiting Nrf2/MRP2 signaling in colorectal cancer (CRC) cells. | dihydromyricetin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 3 | BACKGROUD: Dihydromyricetin (DMY), a natural flavonoid compound from the leaves of the Chinese medicinal herb Vitis heyneana, has been shown to have the potential to combat chemoresistance by inhibiting Nrf2/MRP2 signaling in colorectal cancer (CRC) cells. | dihydromyricetin | NFE2 like bZIP transcription factor 2 | Homo sapiens |
| 4 | Furthermore, DMY could inhibit NF-kappaB/p65 expression, reducing NF-kappaB/p65 translocation to the nucleus to silence Nrf2 signaling, which is necessary for MRP2 expression. | dihydromyricetin | NFE2 like bZIP transcription factor 2 | Homo sapiens |