Title : Activation of the Akt1-CREB pathway promotes RNF146 expression to inhibit PARP1-mediated neuronal death.

Pub. Date : 2020 Dec 22

PMID : 33443209






1 Functional Relationships(s)
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1 Overexpressing constitutively active Akt1 in SH-SY5Y cells or culturing cells with chlorogenic acid (a polyphenol found in coffee that activates Akt1) stimulated the CREB-dependent transcriptional activation of the gene encoding the E3 ubiquitin ligase RNF146. Polyphenols ring finger protein 146 Homo sapiens