Title : Mechanism of SARS-CoV-2 polymerase stalling by remdesivir.

Pub. Date : 2021 Jan 12

PMID : 33436624






2 Functional Relationships(s)
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Compound Name
Protein Name
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1 This translocation barrier causes retention of the RNA 3"-nucleotide in the substrate-binding site of the RdRp and interferes with entry of the next nucleoside triphosphate, thereby stalling RdRp. [[(2R,3S,4R,5S)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2
2 This translocation barrier causes retention of the RNA 3"-nucleotide in the substrate-binding site of the RdRp and interferes with entry of the next nucleoside triphosphate, thereby stalling RdRp. [[(2R,3S,4R,5S)-3,4-dihydroxy-5-methyloxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate ORF1a polyprotein;ORF1ab polyprotein Severe acute respiratory syndrome coronavirus 2