Title : Regulation of polyamine homeostasis through an antizyme citrullination pathway.

Pub. Date : 2021 Aug

PMID : 33432662






5 Functional Relationships(s)
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1 This study reveals an uncovered mechanism for the regulation of polyamine homeostasis through protein arginyl citrullination of antizyme (AZ), a natural inhibitor of ornithine decarboxylase (ODC). Polyamines ornithine decarboxylase 1 Homo sapiens
2 This study reveals an uncovered mechanism for the regulation of polyamine homeostasis through protein arginyl citrullination of antizyme (AZ), a natural inhibitor of ornithine decarboxylase (ODC). Polyamines ornithine decarboxylase 1 Homo sapiens
3 ODC is critical for the cellular production of polyamines. Polyamines ornithine decarboxylase 1 Homo sapiens
4 This paper provides evidence to illustrate that PAD4-mediated AZ citrullination upregulates cellular ODC and polyamines by retarding ODC degradation, thus interfering with the homeostasis of cellular polyamines, which may be an important pathway regulating AZ functions that is relevant to cancer biology. Polyamines ornithine decarboxylase 1 Homo sapiens
5 This paper provides evidence to illustrate that PAD4-mediated AZ citrullination upregulates cellular ODC and polyamines by retarding ODC degradation, thus interfering with the homeostasis of cellular polyamines, which may be an important pathway regulating AZ functions that is relevant to cancer biology. Polyamines ornithine decarboxylase 1 Homo sapiens