Pub. Date : 2021 Aug
PMID : 33432662
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | This study reveals an uncovered mechanism for the regulation of polyamine homeostasis through protein arginyl citrullination of antizyme (AZ), a natural inhibitor of ornithine decarboxylase (ODC). | Polyamines | ornithine decarboxylase 1 | Homo sapiens |
| 2 | This study reveals an uncovered mechanism for the regulation of polyamine homeostasis through protein arginyl citrullination of antizyme (AZ), a natural inhibitor of ornithine decarboxylase (ODC). | Polyamines | ornithine decarboxylase 1 | Homo sapiens |
| 3 | ODC is critical for the cellular production of polyamines. | Polyamines | ornithine decarboxylase 1 | Homo sapiens |
| 4 | This paper provides evidence to illustrate that PAD4-mediated AZ citrullination upregulates cellular ODC and polyamines by retarding ODC degradation, thus interfering with the homeostasis of cellular polyamines, which may be an important pathway regulating AZ functions that is relevant to cancer biology. | Polyamines | ornithine decarboxylase 1 | Homo sapiens |
| 5 | This paper provides evidence to illustrate that PAD4-mediated AZ citrullination upregulates cellular ODC and polyamines by retarding ODC degradation, thus interfering with the homeostasis of cellular polyamines, which may be an important pathway regulating AZ functions that is relevant to cancer biology. | Polyamines | ornithine decarboxylase 1 | Homo sapiens |