Title : Alpha-Lipoic Acid Plays a Role in Endometriosis: New Evidence on Inflammasome-Mediated Interleukin Production, Cellular Adhesion and Invasion.

Pub. Date : 2021 Jan 8

PMID : 33430114






3 Functional Relationships(s)
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1 The present study aims to investigate the potential effect of alpha-lipoic acid (ALA) on NALP-3 and ER-beta expression using a western blot analysis, NALP-3-induced cytokines production by ELISA, migration and invasion of immortalized epithelial (12Z) and stromal endometriotic cells (22B) using a 3D culture invasion assay, and matrix-metalloprotease (MMPs) activity using gelatin zymography. Thioctic Acid estrogen receptor 1 Homo sapiens
2 The present study aims to investigate the potential effect of alpha-lipoic acid (ALA) on NALP-3 and ER-beta expression using a western blot analysis, NALP-3-induced cytokines production by ELISA, migration and invasion of immortalized epithelial (12Z) and stromal endometriotic cells (22B) using a 3D culture invasion assay, and matrix-metalloprotease (MMPs) activity using gelatin zymography. Thioctic Acid estrogen receptor 1 Homo sapiens
3 ALA significantly reduces ER-beta, NALP-3 protein expression/activity and the secretion of IL-1beta and IL-18 in both 12Z and 22B cells. Thioctic Acid estrogen receptor 1 Homo sapiens