Title : Metabolic phenotyping reveals a reduction in the bioavailability of serotonin and kynurenine pathway metabolites in both the urine and serum of individuals living with Alzheimer's disease.

Pub. Date : 2021 Jan 9

PMID : 33422142






4 Functional Relationships(s)
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Compound Name
Protein Name
Organism
1 Metabolism via tryptophan hydroxylase results in serotonin synthesis, whilst metabolism via indoleamine 2,3-dioxygenase (IDO) results in kynurenine and its downstream derivatives. Kynurenine indoleamine 2,3-dioxygenase 1 Homo sapiens
2 Metabolism via tryptophan hydroxylase results in serotonin synthesis, whilst metabolism via indoleamine 2,3-dioxygenase (IDO) results in kynurenine and its downstream derivatives. Kynurenine indoleamine 2,3-dioxygenase 1 Homo sapiens
3 A significant increase in the kynurenine/tryptophan ratio suggests that this may be a result of a shift to the kynurenine metabolic route due to increased IDO activity, potentially as a result of systemic inflammation. Kynurenine indoleamine 2,3-dioxygenase 1 Homo sapiens
4 A significant increase in the kynurenine/tryptophan ratio suggests that this may be a result of a shift to the kynurenine metabolic route due to increased IDO activity, potentially as a result of systemic inflammation. Kynurenine indoleamine 2,3-dioxygenase 1 Homo sapiens