Title : HDAC5 Loss Impairs RB Repression of Pro-Oncogenic Genes and Confers CDK4/6 Inhibitor Resistance in Cancer.

Pub. Date : 2021 Mar 15

PMID : 33419772






2 Functional Relationships(s)
Download
Sentence
Compound Name
Protein Name
Organism
1 Here we demonstrate that HDAC5 deficient for the LXCXE motif interacts with both RB-N (via an FXXXV motif) and RB-C segments, and such interactions are diminished by phosphorlyation of RB serine-249/threonine-252 and threonine-821. Threonine histone deacetylase 5 Homo sapiens
2 Here we demonstrate that HDAC5 deficient for the LXCXE motif interacts with both RB-N (via an FXXXV motif) and RB-C segments, and such interactions are diminished by phosphorlyation of RB serine-249/threonine-252 and threonine-821. Threonine histone deacetylase 5 Homo sapiens