| Protein Name | histone deacetylase 5 |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 10014 |
| Gene Symbol | HDAC5 |
| UniProt | Q9UQL6 (HDAC5_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
87
Total Number of Articles : 92 |
Description |
histone deacetylase 5 |
| Gene Summary |
Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to the class II histone deacetylase/acuc/apha family. It possesses histone deacetylase activity and represses transcription when tethered to a promoter. It coimmunoprecipitates only with HDAC3 family member and might form multicomplex proteins. It also interacts with myocyte enhancer factor-2 (MEF2) proteins, resulting in repression of MEF2-dependent genes. This gene is thought to be associated with colon cancer. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
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