Title : Small Molecule SARM1 Inhibitors Recapitulate the SARM1-/- Phenotype and Allow Recovery of a Metastable Pool of Axons Fated to Degenerate.

Pub. Date : 2021 Jan 5

PMID : 33406435






1 Functional Relationships(s)
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1 We identify a potent and selective small molecule isoquinoline inhibitor of SARM1 NADase that recapitulates the SARM1-/- phenotype and protects axons from degeneration induced by axotomy or mitochondrial dysfunction. isoquinoline sterile alpha and TIR motif containing 1 Homo sapiens