Pub. Date : 2021 Feb 4
PMID : 33400924
5 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Negative regulation of AMPK signaling by high glucose via E3 ubiquitin ligase MG53. | Glucose | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 2 | As a master regulator of metabolism, AMP-activated protein kinase (AMPK) is activated upon energy and glucose shortage but suppressed upon overnutrition. | Glucose | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 3 | As a master regulator of metabolism, AMP-activated protein kinase (AMPK) is activated upon energy and glucose shortage but suppressed upon overnutrition. | Glucose | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 4 | Here, we demonstrate that high glucose represses AMPK signaling via MG53 (also called TRIM72) E3-ubiquitin-ligase-mediated AMPKalpha degradation and deactivation. | Glucose | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |
| 5 | In addition, high glucose deactivates AMPK by ROS-dependent suppression of phosphorylation of AMPKalpha at T172. | Glucose | protein kinase AMP-activated catalytic subunit alpha 2 | Homo sapiens |