Title : C1q/tumor necrosis factor-related protein-6 attenuates TNF-α-induced apoptosis in salivary acinar cells via AMPK/SIRT1-modulated miR-34a-5p expression.

Pub. Date : 2021 Aug

PMID : 33400820






2 Functional Relationships(s)
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1 AraA, an AMPK inhibitor, reversed the effects of CTRP6 on TNF-alpha-induced alterations in the levels of SIRT1, miR-34a-5p, Bcl-2, and cleaved caspase 3 in vitro and ex vivo, whereas activating AMPK by AICAR reversed the decrease in SIRT1 expression and increase in miR-34a-5p expression induced by TNF-alpha. Vidarabine tumor necrosis factor Mus musculus
2 AraA, an AMPK inhibitor, reversed the effects of CTRP6 on TNF-alpha-induced alterations in the levels of SIRT1, miR-34a-5p, Bcl-2, and cleaved caspase 3 in vitro and ex vivo, whereas activating AMPK by AICAR reversed the decrease in SIRT1 expression and increase in miR-34a-5p expression induced by TNF-alpha. Vidarabine tumor necrosis factor Mus musculus