Title : Synthesis of glutathione as a central aspect of PAH toxicity in liver cells: A comparison between phenanthrene, Benzo[b]Fluoranthene and their mixtures.

Pub. Date : 2021 Jan 15

PMID : 33396157






2 Functional Relationships(s)
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1 Transcript (mRNA) levels of glutathione synthesis enzymes - glutathione cysteine ligase catalytical (GCLC) and modifying (GCLM) sub-units and glutathione synthetase (GS) - and Nrf2 translocation to the nucleus were analyzed. Glutathione glutamate-cysteine ligase modifier subunit Homo sapiens
2 The upregulation of GSH was the consequence of Nrf2 signaling activation and increased levels of GCLC, GCLM and GS mRNA observed after exposure to B[b]F, but not during exposure to Phe. Glutathione glutamate-cysteine ligase modifier subunit Homo sapiens