| Protein Name | glutamate-cysteine ligase modifier subunit |
|---|---|
| Organism | Homo sapiens |
| Gene ID | 2730 |
| Gene Symbol | GCLM |
| UniProt | P48507 (GSH0_HUMAN) |
| Relationships |
Total Number of functionally related compound(s) :
116
Total Number of Articles : 142 |
Description |
glutamate-cysteine ligase modifier subunit |
| Gene Summary |
Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, is the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subunit and a light regulatory subunit. Gamma glutamylcysteine synthetase deficiency has been implicated in some forms of hemolytic anemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015] |
| synonyms |
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| Properties | |