Title : The Isothiocyanate Sulforaphane Depends on the Nrf2/γ-GCL/GSH Axis to Prevent Mitochondrial Dysfunction in Cells Exposed to Methylglyoxal.

Pub. Date : 2021 Apr

PMID : 33392911






1 Functional Relationships(s)
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1 Inhibition of gamma-GCL with buthionine sulfoximine (BSO) or silencing of Nrf2 using small interfering RNA (siRNA) against this transcription factor reduced the levels of GSH and abolished the mitochondrial protection promoted by SFN in the MG-treated cells. Glutathione NFE2 like bZIP transcription factor 2 Homo sapiens