Pub. Date : 2021 Apr
PMID : 33383282
6 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Dexmedetomidine Resists Intestinal Ischemia-Reperfusion Injury by Inhibiting TLR4/MyD88/NF-kappaB Signaling. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | In the present study, we aimed to investigate the protective effects of DEX and examine whether its mechanism was associated with the TLR4/MyD88/NF-kappaB signaling pathway. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | RESULTS: DEX preconditioning significantly reduced the intestinal pathological Chiu"s score, serum I-FABP, intestinal TNF-alpha, IL-1beta levels, and the protein expression of TLR4, MyD88, and NF-kappaB in the rats with intestinal I/R injury. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 4 | Similarly, in vitro, DEX pretreatment protected against OGD/R-induced Caco-2 cell damage and inhibited TLR4/MyD88/NF-kappaB signaling, as evidenced by increased cell viability, decreased LDH activity, reduced TNF-alpha and IL-1beta levels, as well as downregulated TLR4, MyD88, and NF-kappaB protein levels. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 5 | Similarly, in vitro, DEX pretreatment protected against OGD/R-induced Caco-2 cell damage and inhibited TLR4/MyD88/NF-kappaB signaling, as evidenced by increased cell viability, decreased LDH activity, reduced TNF-alpha and IL-1beta levels, as well as downregulated TLR4, MyD88, and NF-kappaB protein levels. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |
| 6 | CONCLUSIONS: Our findings suggested that DEX could reduce intestinal I/R injury in rats and OGD/R damage in Caco-2 cells, and this protection might be attributed to antiinflammatory effects and inhibition of the TLR4/MyD88/NF-kappaB signaling pathway. | Dexmedetomidine | nuclear factor kappa B subunit 1 | Homo sapiens |