Pub. Date : 2020 Dec
PMID : 33377659
7 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | CD13 promotes hepatocellular carcinogenesis and sorafenib resistance by activating HDAC5-LSD1-NF-kappaB oncogenic signaling. | Sorafenib | alanyl aminopeptidase, membrane | Homo sapiens |
| 2 | RATIONALE: CD13 is a new marker for liver cancer stem cells (CSCs) that contributes to sorafenib resistance in hepatocellular carcinoma (HCC). | Sorafenib | alanyl aminopeptidase, membrane | Homo sapiens |
| 3 | However, the underlying mechanism of CD13 in HCC sorafenib resistance remains enigmatic. | Sorafenib | alanyl aminopeptidase, membrane | Homo sapiens |
| 4 | Functionally, CD13 promoted HCC proliferation, invasion, cell cycle progression as well as sorafenib resistance. | Sorafenib | alanyl aminopeptidase, membrane | Homo sapiens |
| 5 | A CD13 inhibitor ubenimex in combination with sorafenib, suppressed the tumor growth and attenuated the resistance of HCC cells toward sorafenib in patient-derived xenograft models. | Sorafenib | alanyl aminopeptidase, membrane | Homo sapiens |
| 6 | CONCLUSIONS: CD13 promotes HCC progression and induces sorafenib resistance, mainly via interacting with HDAC5 to prevent the degradation of p65 and activate NF-kB signaling pathway. | Sorafenib | alanyl aminopeptidase, membrane | Homo sapiens |
| 7 | CD13 is a prognostic indicator for HCC patients underwent curative resection as well as a predictor of response to treatment with sorafenib. | Sorafenib | alanyl aminopeptidase, membrane | Homo sapiens |