Title : Discovery of Potent Dual EGFR/HER2 Inhibitors Based on Thiophene Scaffold Targeting H1299 Lung Cancer Cell Line.

Pub. Date : 2020 Dec 24

PMID : 33374155






1 Functional Relationships(s)
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1 Our synthesized compounds were promising, demonstrating high selectivity and affinity for EGFR/HER2, especially the hinge region forming a hydrophobic pocket, which was mediated by hydrogen bonding as well as hydrophobic and electrostatic interactions, as indicated by molecular modeling. Hydrogen epidermal growth factor receptor Homo sapiens