Pub. Date : 2021 Jan
PMID : 33365058
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Metformin alleviates beta-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 2 | Metformin increased the number of autophagosomes, green fluorescent LC3 puncta and the levels of LC3II/I, beclin 1, alpha-SMA and phosphorylated (p)-AMPK in the VSMCs that were treated with beta-glycerophosphate when compared to controls; whereas, calcium deposition and the expression levels of RUNX2 and p-mTOR were found to be decreased. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |
| 3 | The results of the present study suggested that metformin may alleviate beta-glycerophosphate-induced calcification of VSMCs, which may be attributed to the activation of AMPK/mTOR signaling pathway-dependent autophagy. | Metformin | mechanistic target of rapamycin kinase | Homo sapiens |