Title : Metformin alleviates β-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy.

Pub. Date : 2021 Jan

PMID : 33365058






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1 Metformin alleviates beta-glycerophosphate-induced calcification of vascular smooth muscle cells via AMPK/mTOR-activated autophagy. Metformin mechanistic target of rapamycin kinase Homo sapiens
2 Metformin increased the number of autophagosomes, green fluorescent LC3 puncta and the levels of LC3II/I, beclin 1, alpha-SMA and phosphorylated (p)-AMPK in the VSMCs that were treated with beta-glycerophosphate when compared to controls; whereas, calcium deposition and the expression levels of RUNX2 and p-mTOR were found to be decreased. Metformin mechanistic target of rapamycin kinase Homo sapiens
3 The results of the present study suggested that metformin may alleviate beta-glycerophosphate-induced calcification of VSMCs, which may be attributed to the activation of AMPK/mTOR signaling pathway-dependent autophagy. Metformin mechanistic target of rapamycin kinase Homo sapiens