Pub. Date : 2020
PMID : 33364238
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Here, we discovered a small molecule Zharp-99 as a potent inhibitor of necroptosis through blocking the kinase activity of RIPK3. | zharp-99 | receptor-interacting serine-threonine kinase 3 | Mus musculus |
| 2 | Zharp-99 strongly inhibits cellular activation of RIPK3, and MLKL upon necroptosis stimuli. | zharp-99 | receptor-interacting serine-threonine kinase 3 | Mus musculus |
| 3 | Zharp-99 directly blocks the kinase activity of RIPK3 without affecting RIPK1 kinase activity at the tested concentration. | zharp-99 | receptor-interacting serine-threonine kinase 3 | Mus musculus |
| 4 | Thus, our study demonstrates Zharp-99 as a potent inhibitor of RIPK3 kinase and also highlights its potential for further development of new approaches for treating necroptosis-associated inflammatory disorders. | zharp-99 | receptor-interacting serine-threonine kinase 3 | Mus musculus |