PMID-sentid	Pub_year	Sent_text		comp_official_name	comp_offsetprotein_name	organism	prot_offset
33364238-3	2020	Here, we discovered a small molecule Zharp-99 as a potent inhibitor of necroptosis through blocking the kinase activity of RIPK3.	zharp-99	37-45	receptor-interacting serine-threonine kinase 3	Mus musculus	123-128	
33364238-5	2020	Zharp-99 strongly inhibits cellular activation of RIPK3, and MLKL upon necroptosis stimuli.	zharp-99	0-8	receptor-interacting serine-threonine kinase 3	Mus musculus	50-55	
33364238-6	2020	Zharp-99 directly blocks the kinase activity of RIPK3 without affecting RIPK1 kinase activity at the tested concentration.	zharp-99	0-8	receptor-interacting serine-threonine kinase 3	Mus musculus	48-53	
33364238-9	2020	Thus, our study demonstrates Zharp-99 as a potent inhibitor of RIPK3 kinase and also highlights its potential for further development of new approaches for treating necroptosis-associated inflammatory disorders.	zharp-99	29-37	receptor-interacting serine-threonine kinase 3	Mus musculus	63-68