Pub. Date : 2021
PMID : 33363708
4 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Compound 1c (IC50 = 4.70 +- 0.40 muM) and compound 1j (IC50 = 11.18 +- 0.54 muM) inhibited tyrosinase by 4.9 and 2.1-fold, respectively, and did so more potently than kojic acid (IC50 = 23.18 +- 0.11 muM). | kojic acid | tyrosinase | Homo sapiens |
| 2 | Results of docking simulation with mushroom tyrosinase using four docking programs suggested that 1c and 1j bind more strongly than kojic acid to the active site of tyrosinase and supported kinetic findings that both compounds are competitive inhibitors. | kojic acid | tyrosinase | Homo sapiens |
| 3 | Results of docking simulation with mushroom tyrosinase using four docking programs suggested that 1c and 1j bind more strongly than kojic acid to the active site of tyrosinase and supported kinetic findings that both compounds are competitive inhibitors. | kojic acid | tyrosinase | Homo sapiens |
| 4 | Both compounds significantly and dose-dependently reduced tyrosinase activity, and at 10 microM were more potent than kojic acid at 20 microM. | kojic acid | tyrosinase | Homo sapiens |