Pub. Date : 2020
PMID : 33363176
9 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Quercetin Suppresses Apoptosis and Attenuates Intervertebral Disc Degeneration via the SIRT1-Autophagy Pathway. | Quercetin | sirtuin 1 | Rattus norvegicus |
| 2 | Quercetin, a natural flavonoid possessing a specific effect of autophagy stimulation and SIRT1 activation, showed some protective effect on a series of degenerative diseases. | Quercetin | sirtuin 1 | Rattus norvegicus |
| 3 | Based on previous studies, we hypothesized that quercetin might have therapeutic effects on IDD by inhibiting the apoptosis of NP cells and dyshomeostasis of ECM via the SIRT1-autophagy pathway. | Quercetin | sirtuin 1 | Rattus norvegicus |
| 4 | We also found that quercetin promoted the expression of SIRT1 and autophagy in NP cells in a dose-dependent manner. | Quercetin | sirtuin 1 | Rattus norvegicus |
| 5 | Moreover, SIRT1 enzymatic activity inhibitor EX-527, suppressed quercetin-induced autophagy and the protective effect on NP cells, indicating that quercetin protected NP cells against apoptosis and prevented ECM degeneration via SIRT1-autophagy pathway. | Quercetin | sirtuin 1 | Rattus norvegicus |
| 6 | Moreover, SIRT1 enzymatic activity inhibitor EX-527, suppressed quercetin-induced autophagy and the protective effect on NP cells, indicating that quercetin protected NP cells against apoptosis and prevented ECM degeneration via SIRT1-autophagy pathway. | Quercetin | sirtuin 1 | Rattus norvegicus |
| 7 | Moreover, SIRT1 enzymatic activity inhibitor EX-527, suppressed quercetin-induced autophagy and the protective effect on NP cells, indicating that quercetin protected NP cells against apoptosis and prevented ECM degeneration via SIRT1-autophagy pathway. | Quercetin | sirtuin 1 | Rattus norvegicus |
| 8 | Moreover, SIRT1 enzymatic activity inhibitor EX-527, suppressed quercetin-induced autophagy and the protective effect on NP cells, indicating that quercetin protected NP cells against apoptosis and prevented ECM degeneration via SIRT1-autophagy pathway. | Quercetin | sirtuin 1 | Rattus norvegicus |
| 9 | Taken together, our results suggest that quercetin prevents IDD by promoting SIRT1-dependent autophagy, indicating one novel and effective therapeutic method for IDD. | Quercetin | sirtuin 1 | Rattus norvegicus |