Pub. Date : 2021 Aug
PMID : 33356884
3 Functional Relationships(s)Download |
Sentence | Compound Name | Protein Name | Organism |
| 1 | Nicaraven inhibits TNFalpha-induced endothelial activation and inflammation through suppressing NF-kappaB signaling pathway. | nicaraven | nuclear factor kappa B subunit 1 | Homo sapiens |
| 2 | Mechanistically, Nicaraven prevented TNFalpha-induced activation of NF-kappaB signaling pathway by suppressing the phosphorylation of NF-kappaB p65, IkappaBalpha, and IKKalpha/beta, stabilizing IkappaBalpha, and inhibiting the translocation of p65 from cytosol to nucleus. | nicaraven | nuclear factor kappa B subunit 1 | Homo sapiens |
| 3 | Our findings indicated that Nicaraven effectively inhibits TNFalpha-induced endothelial activation and inflammatory response at least partly through inhibiting NF-kappaB signaling pathway. | nicaraven | nuclear factor kappa B subunit 1 | Homo sapiens |